Start with one or two keywords, then combine concepts one at a time. Do not add limiters (date, article type, etc.) until you're sure your keywords are productive.
Use controlled vocabulary to refine and focus results. Many articles have standardized descriptive terms assigned to them so you can easily find related articles.
Other PubMed tips:
MeSH database via PubMed: MeSH tutorial
The Cochrane Database of Systematic Reviews is a comprehensive global medical database. If you find a Cochrane Review related to your topic, it can be an excellent resource for identifying helpful articles as well as offering a valuable perspective on the available evidence.
Types of Cochrane Review:
Intervention reviews assess the benefits and harms of interventions used in healthcare and health policy.
Diagnostic test accuracy reviews assess how well a diagnostic test performs in diagnosing and detecting a particular disease.
Methodology reviews address issues relevant to how systematic reviews and clinical trials are conducted and reported.
Qualitative reviews synthesize qualitative evidence to address questions on aspects of interventions other than effectiveness.
Prognosis reviews address the probable course or future outcome(s) of people with a health problem.
Author Last Name, Author Initials. (Date). Title of article. Cochrane Database of Systematic Reviews. https://doi.org/XXXXXXX
Other ways to find the full-text of an article: